Evidence map›Paper›PMID 40568821›Full record

ArticleAnnals of neurology2025

μ-Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks.

Dajung J Kim, Manyoel Lim, Thiago D Nascimento, Frank Porreca, Robert A Koeppe, Nouchine Hadjikhani, Alexandre F DaSilva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dajung J KimHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.ORCID 0000-0002-4572-0146
Manyoel LimHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Thiago D NascimentoHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Frank PorrecaDepartment of Pharmacology, University of Arizona Health Sciences Center, Tucson, Arizona, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Nouchine HadjikhaniDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alexandre F DaSilvaHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Funding

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)R01NS094413 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALEXANDRE DASILVA · 2015 to 2026
$4.3M
Structural and Molecular Neuroplasticity in Chronic Trigeminal PainK23NS062946 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2009 to 2013
$779k
NINDS NIH HHS K23 NS062946NINDS NIH HHS K23-NS062946NINDS NIH HHS R01 NS094413NINDS NIH HHS R01-NS094413
6 · The paper itself

Abstract

objectiveThe possible impact of meningeal μ-opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation.

methodsWe used positron emission tomography with [

resultsA total of 36 patients with interictal episodic migraine (8 also assessed ictally), 7 patients with ictal chronic migraine, and 22 healthy controls were included in the analysis. Both the episodic migraine and chronic migraine groups showed lower μOR availability in the parietal PMT than healthy controls during the ictal resting phase. No significant differences were observed during the interictal phase. Exploratory analyses on the effects of sex indicated that both healthy women and migraine patients of both sexes showed lower μOR availability in the frontal PMT compared with healthy men in the ictal sustained thermal pain threshold stress condition. Furthermore, the interictal μOR availability in the frontal PMT was negatively associated with headache intensity in the preceding month.

interpretationThe observed variability in PMT μOR availability across the different cortical regions and migraine episodes, along with its association with pain intensity, underscores the critical role of extracerebral mechanisms in migraine pathophysiology. ANN NEUROL 2025;98:777-787.

Indexed as

MeningesMigraine DisordersReceptors, Opioid, muAdultFemaleFentanylHumansMaleMiddle AgedPositron-Emission TomographyYoung AdultcarfentanilFentanylReceptors, Opioid, mu

Identifiers

PMID40568821
PMCPMC12542323

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.