Evidence map›Paper›PMID 40568745›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Regioselective C─H Functionalization by the Combination of Enzymatic and Chemocatalytic Reactions in Water.

Ran Zhu, Xuhua Mo, Tanja Gulder, Tobias A M Gulder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ran ZhuChair of Technical Biochemistry, Department of Chemistry and Food Chemistry, Technical University of Dresden, Bergstraße 66, Dresden, 01069, Germany.
Xuhua MoShandong Key Laboratory of Applied Mycology, School of Life Science, Qingdao Agricultural University, Qingdao, 266109, China.
Tanja GulderOrganic Chemistry - Biomimetic Catalysis, Saarland University, Saarbrücken, 66123, Germany.
Tobias A M GulderChair of Technical Biochemistry, Department of Chemistry and Food Chemistry, Technical University of Dresden, Bergstraße 66, Dresden, 01069, Germany.ORCID 0000-0001-6013-3161

Funding

China Scholarship CouncilDeutsche Forschungsgemeinschaft (DFG) GU 1233/1-1
6 · The paper itself

Abstract

The combination of bio- and chemo-catalytic processes has tremendous potential for the sustainable production of important synthetic building blocks. Such approaches capitalize on the often-high selectivity of enzymes and the broad arsenal of synthetic transformations to access highly functionalized molecules from simple precursors. However, the strict requirement of enzymes for an aqueous reaction environment, often combined with their lack of stability under harsh reaction conditions, makes the development of efficient chemo-enzymatic cascade reactions challenging. Within this work, we developed a chemo-enzymatic platform that combines regioselective enzymatic Halogenation, chemo-catalytic Heck coupling, and an enzyme-catalyzed Hydrolysis reaction (H

Indexed as

WaterBiocatalysisCatalysisHalogenationHydrolysisMolecular StructureStereoisomerismWaterAcrylic acidsChemoenzymatic cascadesEnzymatic halogenationGreen chemistryMicelles

Identifiers

PMID40568745
PMCPMC12363612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.