Evidence map›Paper›PMID 40568741›Full record

ArticleAIDS (London, England)2025

Vaginal microbiome composition in women with HIV undergoing treatment of cervical transformation zone in a screen and treat program in Zambia.

Leeya F Pinder, Pierre Bertrand, Veronica Fertitta, Vincent Cahais, Mulindi Mwanahamuntu, Namakau Nyambe, Samson Chisele, Aaron Lunda Shibemba, Sandrine McKay-Chopin, Cyrille Cuenin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Leeya F PinderDepartment of Obstetrics and Gynecology, Women and Newborn Hospital, Lusaka, Zambia.
Pierre BertrandEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Veronica FertittaEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Vincent CahaisEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Mulindi MwanahamuntuUniversity Teaching Hospital.
Namakau NyambeDepartment of Obstetrics and Gynecology, Women and Newborn Hospital, Lusaka, Zambia.
Samson ChiseleDepartment of Obstetrics and Gynecology, Women and Newborn Hospital, Lusaka, Zambia.
Aaron Lunda ShibembaDepartment of Obstetrics and Gynecology, Women and Newborn Hospital, Lusaka, Zambia.
Sandrine McKay-ChopinEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Cyrille CueninEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Eric LucasEarly Detection, Prevention & Infections Branch, International Agency for Research on Cancer, Lyon, France.
Michael KorenjakEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Richard MuwongeEarly Detection, Prevention & Infections Branch, International Agency for Research on Cancer, Lyon, France.
Akram GhantousEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Zdenko HercegEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Groesbeck P ParhamUniversity Teaching Hospital.
Jiri ZavadilEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.
Partha BasuEarly Detection, Prevention & Infections Branch, International Agency for Research on Cancer, Lyon, France.
Tarik GheitEpigenomics and Mechanisms Branch, International Agency for Research on Cancer, Lyon, France.

Funding

Development, field testing and evaluation of the efficacy of a hand-held, portable and affordable thermo-coagulator to prevent cervical cancer in low- and middle-income countriesUH2CA202721 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI BASU, PARTHA · 2016 to 2017
$925k
NCI NIH HHS UH2 CA202721World Health Organization 001
6 · The paper itself

Abstract

This study assessed the vaginal microbiome in women with HIV undergoing cervical transformation zone treatment in Zambia. 16S rRNA sequencing showed lower microbial diversity in successful outcomes (N = 18) than those with treatment failure (N = 17) treatment outcome, with Lactobacillus abundance correlated with success. Moreover, HPV-negative women (N = 12) had higher Lactobacillus levels and less pathogens than HPV-positive women (N = 12). These findings suggest a Lactobacillus-dominated microbiome may be associated with positive treatment outcomes.

Indexed as

HIV InfectionsMicrobiotaVaginaAdultDNA, BacterialDNA, RibosomalFemaleHumansLactobacillusMiddle AgedRNA, Ribosomal, 16SSequence Analysis, DNATreatment OutcomeYoung AdultZambiaDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S

Identifiers

PMID40568741
PMCPMC12204225

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.