Evidence map›Paper›PMID 40568740›Full record

ArticleAIDS (London, England)2025

Higher levels of cell-associated HIV-1 RNA transcripts predict risk of viral blips: implications for clinical management and cure research.

Kazuo Suzuki, Angelique Levert, Emma Yoo, Lucette A Cysique, Takaomi Ishida, Nick Olsen, Bruce James Brew, John Zaunders

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kazuo SuzukiSt Vincent's Centre for Applied Medical Research, NSW State Reference Laboratory for HIV.
Angelique LevertSt Vincent's Centre for Applied Medical Research, NSW State Reference Laboratory for HIV.
Emma YooSt Vincent's Centre for Applied Medical Research, NSW State Reference Laboratory for HIV.
Lucette A CysiqueDepartments of Neurology and Immunology and Peter Duncan Neurosciences Unit, St Vincent's Hospital.
Takaomi IshidaDenka Co. Ltd, Tokyo, Japan, Japan.
Nick OlsenStats Central, Mark Wainwright Analytical Centre.
Bruce James BrewSt Vincent's Clinical School, Faculty of Medicine, UNSW Sydney.
John ZaundersSt Vincent's Centre for Applied Medical Research, NSW State Reference Laboratory for HIV.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesized that high levels of cell-associated HIV-1 RNA transcripts (CA-HIV-RNA) led to an increased chance of subsequent viremic blips. In a prospective study, we followed 61 virally suppressed participants for four years. Baseline log10 CA-HIV-RNA was strongly associated with future blip in unadjusted [odds ratio (OR) 3.2, 95% confidence interval (95% CI) = 2.1-5.1, P < 0.0001] and adjusted models. A threshold of more than 91 copies/106 cells predicted blips with 71% sensitivity and 67% specificity (AUC = 0.73, 95% CI: 0.66-0.79).

Indexed as

HIV-1HIV InfectionsRNA, ViralViral LoadViremiaAdultFemaleHumansMaleMiddle AgedProspective StudiesRNA, Viral

Identifiers

PMID40568740
PMCPMC12487663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.