Evidence map›Paper›PMID 40568701›Full record

ArticleFrontiers in cellular and infection microbiology2025

AliC and AliD of nonencapsulated

Courtney D Thompson, Md Fahim Khan, Lucas R G Crosby, Shelby G Holcomb, Ana G Jop Vidal, Jorge E Vidal, Larry S McDaniel, Lance E Keller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Regulation of PBP2x Surface Localization byPathogens (Basel, Switzerland) · 2026
    Article
  3. Frontiers in tuberculosis · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Courtney D ThompsonDepartment of Biological Sciences, Mississippi College, Clinton, MS, United States.
Md Fahim KhanDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.
Lucas R G CrosbyDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.
Shelby G HolcombDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.
Ana G Jop VidalDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.
Jorge E VidalDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.
Larry S McDanielDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.
Lance E KellerDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States.

Funding

HEMOGLOBIN-INDUCED VIRULENCE IN STREPTOCOCCUSPNEUMONIAER21AI151571 · NIAID · UNIVERSITY OF MISSISSIPPI MED CTR · PI AKERLEY, BRIAN, EICHENBAUM, ZEHAVA · 2021 to 2022
$441k
DISSEMINATION OF MACROLIDE RESISTANCE ELEMENTS IN STREPTOCOCCUS PNEUMONIAER21AI144571 · NIAID · UNIVERSITY OF MISSISSIPPI MED CTR · PI STEPHENS, DAVID S, TZENG, YIH-LING · 2019 to 2020
$397k
NIAID NIH HHS R21 AI144571NIAID NIH HHS R21 AI151571
6 · The paper itself

Abstract

Introduction: Nonencapsulated Methods: To test this a mutant library of AliC and AliD regulated genes was used in Results: Two mutant genes in our library, ∆ Conclusion: This research demonstrates that proteins encoded by genes regulated by AliC and AliD alter susceptibility to host-derived mechanisms for bacterial clearance and increases bacterial survival in response to ROS.

Indexed as

Bacterial ProteinsPneumococcal InfectionsReactive Oxygen SpeciesStreptococcus pneumoniaeVirulence FactorsAnimalsDisease Models, AnimalHydrogen PeroxideLarvaMothsPhagocytosisVirulenceBacterial ProteinsHydrogen PeroxideReactive Oxygen SpeciesVirulence FactorsGalleria mellonellahost-pathogenoligopeptide transporterStreptococcus pneumoniaevirulence factor

Identifiers

PMID40568701
PMCPMC12187840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.