Evidence map›Paper›PMID 40568674›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Teresa Kleinz, Francesco Cavallieri, Max Borsche, Giulia Toschi, Franco Valzania, Valentina Fioravanti, Enza Maria Valente, Pierfrancesco Mitrotti, Micol Avenali, Simone Zittel and 17 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Francesco Cavallieri
Max Borsche
Giulia Toschi
Franco Valzania
Valentina Fioravanti
Enza Maria Valente
Pierfrancesco Mitrotti
Micol Avenali
Simone Zittel
Rommi Born
Michele Matarazzo
Alessio Di Fonzo
Edoardo Monfrini
Mandy Radefeldt
Letizia Santinelli
Norman Griebner
Cholpon Shambetova
Max Brand
Carolin Gabbert
Cornelis Blauwendraat
Joanne Trinh
Christian Beetz
Peter Bauer
Norbert Brüggemann
Global Parkinson’s Genetics Program (GP2)
Christine Klein

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Objectives: To clinically and biologically characterize individuals with PARK- Methods: We conducted a literature review following the MDSGene database protocol, alongside detailed phenotyping of 11 PARK- Results: 83 patients (74 from the literature) were included in the analysis. The median age at onset was 54 (IQR: 46-61) years. Typical Parkinsonism with a favorable dopaminergic response was observed in all patients. In our cohort, the mean MDS-UPDRS III score was 38.5±21.8 points. Autonomic symptoms were present in all individuals, and 10/11 patients had hyposmia. Several non-motor symptoms were reported for the first time in PARK- Conclusion: While PARK-

Identifiers

PMID40568674
PMCPMC12191082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.