Evidence map›Paper›PMID 40568642›Full record

ArticleRwanda journal of medicine and health sciences2023

Prognostic Significance of Alpha-Fetoprotein in Staging of Chronic Hepatitis B Infection.

Olubunmi Gloria Ayelagbe, Ibrahim Eleha Suleiman, Olutoyin Catherine Adekunle, Adebayo Lawrence Adedeji

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Article in Rwanda journal of medicine and health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Olubunmi Gloria AyelagbeChemical Pathology Department, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Ibrahim Eleha SuleimanChemical Pathology Department, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Olutoyin Catherine AdekunleDepartment of Medical Microbiology and Parasitology, Osun State University, Osogbo, Nigeria.
Adebayo Lawrence AdedejiDepartment of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ascertaining the stage of chronic hepatitis-B infection (CHBI) remains one of the major predicaments to effective therapeutic decision. There is pressing need to forestall dearth of such reliable biomarker(s). Despite the promising tendency of alpha-fetoprotein (AFP), it has not been assessed in staging CHBI. Objective: This study was to determine the prognosis of serum AFP as a biomarker for staging CHBI. Methods: Participants were grouped into three based on their hepatitis-B envelope antigen (HBeAg) status and alanine aminotransferase (ALT) level. By denoting HbeAg(+) as (EP), HbeAg(-) as (EN), elevated ALT as (H) and normal ALT as (I), the stages were EPH, ENH and ENI. AFP was assayed, One-way ANOVA, Multivariate linear regression and area under curve were adopted for the analysis. Results: AFP was significantly elevated, (P < 0.05) in EPH, which equally has the highest prevalence of elevated AFP (64.7%). After adjusting for confounding factors, odds ratio was 1.438 (95% CI, 0.62-1.948), while area under the curve for predicting EPH was (0.828, 95% CI, 0.778 -0.895). Conclusions: The finding of elevated AFP in CHBI is an independent prognostic marker of EPH. It is often associated with necroinflammation; thus, it is a reliable indicator for treatment initiation.

Indexed as

Alanine aminotransferaseAlpha-fetoproteinChronic hepatitis-B infectionHepatitis-B e-antigenHepatitis-B virus

Identifiers

PMID40568642
PMCPMC12110496

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