Evidence map›Paper›PMID 40568587›Full record

ArticleFrontiers in immunology2025

Plasma proteomic profiling of hospitalized patients co-infected with HIV and SARS-CoV-2.

Xinyu Zhang, Xuan Yan, Jinfeng Sun, Yueming Shao, Wei Song, Tangkai Qi, Zhenyan Wang, Yang Tang, Jianjun Sun, Jingna Xun and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xinyu ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xuan YanDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jinfeng SunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yueming ShaoDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wei SongDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Tangkai QiDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhenyan WangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yang TangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jianjun SunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jingna XunDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zichen SongDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shuibao XuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Junyang YangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jiangrong WangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Renfang ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinzhong ShenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The interaction between human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections presents a critical challenge to immunopathogenesis. While HIV infection induces progressive CD4 Methods: Liquid chromatography-tandem mass spectrometry was used to analyze the plasma protein profiles in three matched groups: (1) seven hospitalized patients with HIV and SARS-CoV-2 coinfection, (2) seven people living with HIV (PLWH) who tested negative for SARS-CoV-2, and (3) seven healthy controls. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed on the differentially expressed proteins (DEPs). Results: We quantified 5,373 proteins across 21 samples and identified significant alterations in multiple proteins in people living with HIV (PLWH) with COVID-19 compared to both PLWH and healthy controls. These DEPs were associated with inflammatory responses, immune cell migration, degranulation, and, notably, the complement and coagulation cascades. In addition, we identified DEPs associated with SARS-CoV-2 infection, including viral receptors, proteases, transcription factors, and kinases. Conclusions: The proteomic profile highlighted the disruption caused by COVID-19 in immunomodulation, thrombosis, and viral entry pathways in PLWH. Further validation of these signatures could improve risk stratification and tailored interventions for this vulnerable patient cohort.

Indexed as

Blood ProteinsCoinfectionCOVID-19HIV InfectionsProteomeSARS-CoV-2AdultFemaleHospitalizationHumansMaleMiddle AgedProteomicsTandem Mass SpectrometryBlood ProteinsProteomecoinfectionCOVID-19HIVproteomicSARS- CoV- 2

Identifiers

PMID40568587
PMCPMC12187658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.