ArticleNeuroimage. Reports2023
Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy.
Article in Neuroimage. Reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06767410 (A Multi-domain Intervention to Constrast Cognitive Decline in Healthy Aging), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-domain Intervention to Constrast Cognitive Decline in Healthy Aging
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurobiological effects of music-making interventions for older adults: a systematic review.Aging clinical and experimental research · 2025Pooled it
- The effects of music-based interventions on cognitive function in cognitively normal older adults: a systematic review and meta-analysis.Frontiers in psychology · 2025Pooled it
- Quality of life in older adults is enhanced by piano practice: Results from a randomized controlled trial.Annals of the New York Academy of Sciences · 2025Trial
- Acquisition of musical skills and abilities in older adults-results of 12 months of music training.BMC geriatrics · 2024Trial
- Cognitive enrichment through art: a randomized controlled trial on the effect of music or visual arts group practice on cognitive and brain development of young children.BMC complementary medicine and therapies · 2024Trial
- The sound of longevity: music and technology for healthy ageing.Aging clinical and experimental research · 2026Review
- Protocol for an unblinded randomised controlled feasibility trial of Piano Instruction for Adult Novices as Online Cognitive intervention (PIANO-Cog): a novel remote piano training programme for cognitive and motor functions in older age.Pilot and feasibility studies · 2025Article
- Article
- Subcortical gray matter aging and attentional control in amateur musicians and nonmusicians.Annals of the New York Academy of Sciences · 2025Article
- Understanding Music Participation for Adults With Down Syndrome.Journal of intellectual disability research : JIDR · 2025Article
- Never too late to start musical instrument training: Effects on working memory and subcortical preservation in healthy older adults across 4 years.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Age-related neural changes underlying long-term recognition of musical sequences.Communications biology · 2024Article
- Musical activity in a subsample of the German National Cohort study.Scientific reports · 2024Article
- Article
- Structural and Functional Changes in the Brains of Guitarist Musicians: Volumetric, VBM, and Resting State fMRI Study.Journal of clinical practice and research · 2024Article
- The effects of musicality on brain network topology in the context of Alzheimer's disease and memory decline.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Sensorimotor Impairment in Aging and Neurocognitive Disorders: Beat Synchronization and Adaptation to Tempo Changes.Journal of Alzheimer's disease : JAD · 2024Article
- Age and familiarity effects on musical memory.PloS one · 2024Article
- Music and the aging brain - Exploring the role of long-term Carnatic music training on cognition and gray matter volumes.Journal of neurosciences in rural practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal aging is associated with brain atrophy and cognitive decline. Working memory, involved in cognitive functioning and daily living, is particularly affected. Music training gained momentum in research on brain plasticity and possible transfer effects of interventions on working memory, especially in the context of healthy aging. This longitudinal voxel-based morphometry study evaluated effects of 6-month music interventions on grey matter volume plasticity and auditory working memory performance in 132 healthy older adults. This study is part of a randomized controlled trial comparing two interventions: piano practice (experimental group) and musical culture (musical listening awareness, active control). We report significant grey matter volume increase at whole-brain level in the caudate nucleus, Rolandic operculum and inferior cerebellum when merging both groups, but no group differences. Cerebellar grey matter increase, training intensity metrics and sleep were positively associated with tonal working memory improvement. Digit Span Backward verbal working memory performance also increased. Using region of interest analyses, we showed a group difference in the right primary auditory cortex grey matter volume, decreasing in the musical group while staying stable in the piano group. In contrast, a significant 6-month whole-brain atrophy pattern consistent with longer-term investigations of the aging brain was revealed. We argue that education for seniors should become a major policy priority in the framework of healthy aging, to promote brain plasticity and cognitive reserve, through stimulating group interventions such as music-making and active listening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.