Evidence map›Paper›PMID 40568319›Full record

ArticleiScience2025

Microendoscopic calcium imaging in motor cortices of macaques during rest and movement.

Anne-Caroline Martel, Damien Pittard, Annaelle Devergnas, Benjamin Risk, Jonathan J Nassi, Waylin Yu, Joshua D Downer, Thomas Wichmann, Adriana Galvan

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne-Caroline MartelEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Damien PittardEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Annaelle DevergnasEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Benjamin RiskUdall Center of Excellence for Parkinson's Disease Research, Emory University, Atlanta, GA 30329, USA.
Jonathan J NassiInscopix Inc., Mountain View, CA 94040, USA.
Waylin YuInscopix Inc., Mountain View, CA 94040, USA.
Joshua D DownerInscopix Inc., Mountain View, CA 94040, USA.
Thomas WichmannEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Adriana GalvanEmory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
NIH HHS P51 OD011132
6 · The paper itself

Abstract

The study of motor cortices in non-human primates is relevant to our understanding of human motor control, both in healthy conditions and in movement disorders. Calcium imaging and miniature microscopes allow the study of multiple genetically identified neurons with excellent spatial resolution. We used this method to examine activity patterns of projection neurons in deep layers of the supplementary motor (SMA) and primary motor areas (M1) in four rhesus macaques. We implanted gradient index lenses and expressed GCaMP6f to image calcium transients while the animals were at rest or engaged in an arm-reaching task. We tracked the activity of SMA and M1 neurons across conditions, examined cell pairs for synchronous activity, and assessed whether SMA and M1 neuronal activation followed specific sequential activation patterns. We demonstrate the value of

Indexed as

Behavioral neuroscienceSystems neuroscienceTechniques in neuroscience

Identifiers

PMID40568319
PMCPMC12192352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.