ArticleCureus2025
Evaluation of Atherogenic Indexes in Patients With Lichen Planopilaris: A Case-Control Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionLichen planopilaris (LPP) is a chronic cicatricial alopecia characterized by lymphocytic inflammation leading to permanent hair follicle destruction. It is associated with several systemic conditions, including hypothyroidism, dyslipidemia, hypertension, and an increased risk for cardiovascular disease. This study aims to investigate the relationship between serum lipid parameters and atherogenic indexes to evaluate the cardiovascular risk status in patients with LPP.
methodsThis retrospective study was conducted with 115 LPP patients and 115 healthy controls without LPP. Serum total cholesterol, triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were retrieved from hospital records. Atherogenic Index of Plasma (AIP), Castelli Risk Index (CRI) I and II, and Atherogenic Coefficient (AC) were calculated based on lipid profiles.
resultsLPP patients had significantly higher serum TG, total cholesterol, LDL, non-HDL cholesterol, CRI-I, CRI-II, and AC. Additionally, LPP patients were more likely to fall into the high-risk category for CRI-I, CRI-II, and AC.
conclusionsOur study shows that patients with LPP have a higher pro-atherogenic lipid profile and atherogenic indexes. Systemic inflammation and peroxisome proliferator-activated receptor signaling dysregulation may underlie this association, necessitating closer cardiovascular and lipid monitoring in LPP patients.
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