ReviewCureus2025
How Obesity Complicates Breast Cancer Care: Insights From a Systematic Review of Case Reports.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Postbiotics as Emerging Strategy Targeting Obesity- and Aging-Related Breast Cancer-Prospects in Prophylaxis and Therapy.Life (Basel, Switzerland) · 2026Review
- Article
- Socio-Demographic Inequalities in Diagnostic Delays of Breast Cancer: A Multistage Time-to-Diagnosis Analysis.Current oncology (Toronto, Ont.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global rise in obesity has intersected with increasing breast cancer incidence, generating a critical need to understand how excess adiposity affects diagnostic accuracy, treatment delivery, and patient outcomes. Although large epidemiologic studies have established associations between obesity and worse breast cancer prognosis, individual-level clinical nuances remain underrepresented. This review systematically evaluates case-based evidence to identify how obesity contributes to diagnostic delays and treatment complications in breast cancer care. This systematic review was conducted according to PRISMA 2020 guidelines and registered with PROSPERO. Databases searched included PubMed, Embase, Scopus, and Google Scholar through April 2025, using terms related to breast cancer, obesity, and case reports. Eligible studies included English-language case reports or series describing diagnostic or therapeutic complications in obese women with breast cancer. The Joanna Briggs Institute checklist was used to assess methodological quality. Nine patients from eight reports met inclusion criteria. Thematic analysis revealed four key domains in which obesity affected care: delayed or misattributed diagnosis, increased risk of surgical site infections and reconstructive failure, altered metabolism and pharmacokinetics leading to treatment toxicity or underdosing, and compounded clinical complexity due to multimorbidity. Cases included rare infections, malabsorption of endocrine therapy post-bariatric surgery, and fatal toxicities amplified by obesity-related comorbidities. Obesity introduces clinically significant barriers throughout breast cancer diagnosis and treatment. This review emphasizes how real-world patient cases echo trends from population studies while revealing additional mechanistic and procedural challenges. Greater awareness of obesity-specific risks can inform personalized strategies to mitigate diagnostic errors, optimize treatment efficacy, and improve outcomes amid the ongoing obesity epidemic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.