Evidence map›Paper›PMID 40568261›Full record

ArticleCureus2025

An Uncommon Presentation of Crowned Dens Syndrome Without Systemic Inflammation.

Pavan Sakhamuru, Manav Nayeni, Ryan Nazari, Kazi Syed, Kenneth Miller

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pavan SakhamuruCollege of Osteopathic Medicine, Kansas City University, Kansas City, USA.
Manav NayeniCollege of Osteopathic Medicine, Kansas City University, Kansas City, USA.
Ryan NazariCollege of Osteopathic Medicine, Kansas City University, Kansas City, USA.
Kazi SyedCollege of Osteopathic Medicine, Kansas City University, Kansas City, USA.
Kenneth MillerPhysical Medicine and Rehabilitation, Kansas City Veterans Affairs (VA) Medical Center, Kansas City, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crowned Dens Syndrome (CDS) is a rare but important consideration in the differential diagnosis of cervical spine pain in older adults. CDS is characterized by calcium pyrophosphate dihydrate (CPPD) crystal deposition around the odontoid process, often leading to symptoms that overlap with more common conditions such as rheumatoid arthritis (RA), meningitis, or cervical spondylosis. We report the case of a 74-year-old male with chronic neck pain and restricted cervical range of motion. Advanced imaging revealed characteristic calcifications surrounding the odontoid process, pannus formation, and erosive changes at the C1-C2 articulation, consistent with CDS. Clinical evaluation supported a diagnosis of CPPD-related CDS. The patient was successfully managed conservatively with nonsteroidal anti-inflammatory drugs and physical therapy, with notable symptomatic improvement over time. This case reinforces the utility of CT imaging in diagnosing CDS and differentiating it from other inflammatory or degenerative cervical conditions. Awareness of CDS and a high index of suspicion are essential for early diagnosis, appropriate treatment, and avoidance of unnecessary interventions. Conservative management remains effective in most cases; however, further studies are necessary to evaluate alternative therapies for refractory presentations.

Indexed as

atlanto-axial jointcalcium pyrophosphate dihydrate crystal depositioncdscervical spine anomalieschronic neck paincrowned dens syndromeodontoid process

Identifiers

PMID40568261
PMCPMC12194727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.