ArticleCureus2025
The Treatment Response and Safety Profile for Mirabegron in Women With Overactive Bladder and Hypertension.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective Mirabegron, an established treatment for overactive bladder (OAB), is contraindicated in patients with uncontrolled hypertension. Inevitably, there is concern among clinicians and patients regarding its use in patients with well-controlled hypertension. In this study, we aimed to investigate the efficacy of mirabegron in patients with well-controlled hypertension, as well as its adverse effects. Methods This retrospective study involved women with well-controlled hypertension who used mirabegron for the treatment of OAB between August 1, 2017, to July 31, 2020. Medical notes were reviewed from the time of initiation of mirabegron up to 12 months post-treatment. The indicators of response measured were frequency of maturation and nocturia. The sense of urgency and urge incontinence were assessed as well. Safety of the drug was evaluated by documenting the number of hypertensive episodes and recording side effects such as dry mouth, dry eyes, headache, and rashes. Results Forty-six patients with OAB and hypertension were included in the study. Of them, 38 patients (73.6%) had improvement in OAB symptoms following mirabegron therapy. Median urinary frequency improved from 1.5 hours to two hours after mirabegron treatment. Twenty-three of the patients stopped experiencing nocturia one month after starting mirabegron. Sixteen patients (76.2%) experienced improvement in urge symptoms while 19 patients (86.4%) experienced improvement in urge incontinence. Of note, 38 patients (78.2%) did not experience any side effects at all, while a small proportion of the patients (n=4, 8.7%) experienced anticholinergic side effects. Three patients (6.5%) experienced an increase in blood pressure after mirabegron use; no additional anti-hypertensive agents were used as mirabegron was stopped once an increase in blood pressure was noted. Conclusions Mirabegron is efficacious in improving OAB symptoms. It is well tolerated by hypertensive patients and may be used in the long term for symptom control. Home blood pressure monitoring may aid in the earlier detection of worsening control in the small segment of patients in whom mirabegron is not suitable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.