Evidence map›Paper›PMID 40568180›Full record

ArticlebioRxiv : the preprint server for biology2025

Linker Histone H1.5 Contributes to Centromere Integrity in Human Cells.

Ankita Saha, Minh Bui, Daniël P Melters, Ganesan Arunkumar, Songjoon Baek, Reda S Bentahar, Yamini Dalal

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ankita SahaNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.ORCID 0000-0002-0349-4400
Minh BuiNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.ORCID 0000-0002-7984-3275
Daniël P MeltersNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.ORCID 0000-0003-4809-0562
Ganesan ArunkumarNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.ORCID 0000-0002-9966-3511
Songjoon BaekNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.ORCID 0000-0002-8452-5167
Reda S BentaharNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.
Yamini DalalNational Cancer Institute, Centre for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, Maryland, USA.ORCID 0000-0002-7655-6182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian H1 linker histones comprise a group of 11 non-allelic variants which have key roles in modulating chromatin. H1 variant specific genomic distribution contributes to fine tuning regulation of gene expression and chromatin architecture. Contradictory reports on the presence and role of H1 histones at centromeres led us to further investigate whether H1s impact centromeric chromatin. In this study, we focused on H1.5 and by

Identifiers

PMID40568180
PMCPMC12191105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.