Evidence map›Paper›PMID 40568179›Full record

ArticlebioRxiv : the preprint server for biology2024

Enhanced Protein-Protein Interaction Discovery via AlphaFold-Multimer.

Ah-Ram Kim, Yanhui Hu, Aram Comjean, Jonathan Rodiger, Stephanie E Mohr, Norbert Perrimon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ah-Ram KimDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9597-6759
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1494-1402
Aram ComjeanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Jonathan RodigerDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Stephanie E MohrDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9639-7708
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Characterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2M
Functional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI MOHR, STEPHANIE E · 2019 to 2023
$6.8M
NIAMS NIH HHS R01 AR057352NIGMS NIH HHS P41 GM132087
6 · The paper itself

Abstract

Accurately mapping protein-protein interactions (PPIs) is critical for elucidating cellular functions and has significant implications for health and disease. Conventional experimental approaches, while foundational, often fall short in capturing direct, dynamic interactions, especially those with transient or small interfaces. Our study leverages AlphaFold-Multimer (AFM) to re-evaluate high-confidence PPI datasets from

Identifiers

PMID40568179
PMCPMC12191236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.