Evidence map›Paper›PMID 40568096›Full record

ArticlebioRxiv : the preprint server for biology2025

Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis during

Valeria Silva, Robert Scott, Paulina Guajardo, Haojiang Luan, Ruben Herzog, Benjamin H White, John Ewer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Valeria SilvaInstituto de Neurociencias, and Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile.ORCID 0000-0003-4598-0973
Robert ScottLaboratory of Molecular Biology, National Institute of Mental Health, NIH, Bethesda, Maryland, USA.ORCID 0009-0000-0355-7996
Paulina GuajardoInstituto de Neurociencias, and Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile.
Haojiang LuanLaboratory of Molecular Biology, National Institute of Mental Health, NIH, Bethesda, Maryland, USA.
Ruben HerzogUniversité de la Sorbonne, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France.
Benjamin H WhiteLaboratory of Molecular Biology, National Institute of Mental Health, NIH, Bethesda, Maryland, USA.
John EwerInstituto de Neurociencias, and Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile.ORCID 0000-0002-6806-3628

Funding

Identifying Neural Substrates of Behavior in Drosophila MelanogasterZIAMH002800 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI WHITE, BENJAMIN H · 2009 to 2025
$29.2M
Intramural NIH HHS ZIA MH002800
6 · The paper itself

Abstract

Neuromodulators and peptide hormones play important roles in regulating animal behavior. A well-studied example is ecdysis, which is used by insects to shed their exoskeleton at the end of each molt. Ecdysis is initiated by Ecdysis Triggering Hormone (ETH) and Eclosion Hormone (EH), which interact via positive feedback to coordinate the sequence of behavioral and physiological changes that cause exoskeleton shedding. Whereas the cell types targeted by ETH are well characterized, those targeted by EH have remained largely unknown due to limited characterization of the EH receptor (EHR). A gene encoding an EHR has been described in the oriental fruit fly,

Indexed as

adult emergenceguanylate cyclaseinsectsmoltingNeurohormoneneuromodulationneuropeptides

Identifiers

PMID40568096
PMCPMC12190907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.