Evidence map›Paper›PMID 40568079›Full record

ArticlebioRxiv : the preprint server for biology2025

An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafish.

Leanne E Iannucci, Velanganni Selvaraj Maria Thomas, Micaela R Murphy, Caitlin E T Donahue, William K Anderson, Catherine E Rogers, Allison J Saul, Katherine W Rogers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Leanne E IannucciUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.ORCID 0000-0001-5556-4442
Velanganni Selvaraj Maria ThomasUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.
Micaela R MurphyUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.
Caitlin E T DonahueUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.ORCID 0000-0002-0836-6731
William K AndersonUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.
Catherine E RogersUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.ORCID 0009-0002-5594-0764
Allison J SaulUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.
Katherine W RogersUnit on Developmental Signaling, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20814, USA.ORCID 0000-0001-5700-2662

Funding

Decoding developmental signaling during zebrafish embryogenesisZIAHD009002 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROGERS, KATHERINE · 2022 to 2025
$5.1M
Intramural NIH HHS ZIA HD009002
6 · The paper itself

Abstract

Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in basic and translational research. Here, we introduce an optogenetic toolkit comprised of 1) a zebrafish-optimized FGF signaling activator, 2) a single-transcript Nodal signaling activator, and 3) a previously established BMP signaling activator. We thoroughly characterize this suite of tools in zebrafish embryos and show that they provide tunable, light-dependent spatiotemporal control of signaling

Indexed as

BMPembryogenesisFGFmolecular optogeneticsNodalsignalingzebrafish

Identifiers

PMID40568079
PMCPMC12190770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.