Evidence map›Paper›PMID 40568013›Full record

ReviewMaterials today. Bio2025

Graphene-based wearable biosensors for point-of-care diagnostics: From surface functionalization to biomarker detection.

Jiawen Song, Yang Luo, Zhuang Hao, Menglong Qu, Cong Huang, Ziran Wang, Jun Yang, Qingrou Liang, Yuan Jia, Qiuming Song and 2 more

Abstract readReview
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  7. Cross-Platform Biosensing of Immune Receptors Using Peptide-Functionalized Graphene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Emerging Role of NbSensors (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiawen SongSchool of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
Yang LuoState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China.
Zhuang HaoSchool of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
Menglong QuSchool of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
Cong HuangState Key Laboratory of Robotics and Systems, School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Ziran WangKey Laboratory of High-efficiency and Clean Mechanical Manufacture of MOE, School of Mechanical Engineering, Shandong University, Jinan, 250061, China.
Jun YangSino-German College of Intelligent Manufacturing, Shenzhen Technology University, Shenzhen, 518118, China.
Qingrou LiangSino-German College of Intelligent Manufacturing, Shenzhen Technology University, Shenzhen, 518118, China.
Yuan JiaSino-German College of Intelligent Manufacturing, Shenzhen Technology University, Shenzhen, 518118, China.
Qiuming SongSino-German College of Intelligent Manufacturing, Shenzhen Technology University, Shenzhen, 518118, China.
Qiuting ZhangSchool of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.
Sida LuoSchool of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing demand for non-invasive, real-time health monitoring has driven the development of graphene-based wearable biosensors for point-of-care (POC) diagnostics. This review explores the surface functionalization of graphene and its critical role in enhancing the performance of wearable biosensors for biomarker detection. Leveraging graphene's exceptional electrical, mechanical, and biocompatible properties, we discuss how surface functionalization-such as covalent and non-covalent functionalization, biomolecular probes, and passivation layers-enable highly sensitive and selective detection of biomarkers in biofluids. We categorize biomarkers based on their physical properties and explore various wearable designs, including patches, contact lenses, microneedles, and textiles, highlighting their integration into POC devices. Furthermore, we examine the challenges and opportunities in translating graphene-based sensors from the lab to real-world applications, emphasizing the importance of biocompatibility and surface functionalization for improved performance. By bridging the gap between material science and biomedical engineering, this review provides a roadmap for the development of next-generation graphene biosensors that could revolutionize personalized medicine and point-of-care diagnostics.

Indexed as

BiomarkersElectrochemical sensorGrapheneGraphene field-effect transistorIntegration and applicationSurface functionalization

Identifiers

PMID40568013
PMCPMC12190207

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.