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ArticleOpen forum infectious diseases2025

Risk and Distribution of Metastatic Infections by Primary Infection Focus in

Seongman Bae, Min Soo Kook, Euijin Chang, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seongman BaeDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-6375-3657
Min Soo KookDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0000-1191-0761
Euijin ChangDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Jiwon JungDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-4333-3270
Min Jae KimDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Yong Pil ChongDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-1672-3185
Sung-Han KimDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-6596-8253
Sang-Ho ChoiDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-4972-4531
Sang-Oh LeeDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Yang Soo KimDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: This retrospective cohort study analyzed 1725 patients diagnosed with SAB. We assessed the incidence and distribution of metastatic infections within the cohort, stratifying the data by the timing postdiagnosis and the primary infection focus. Results: In the cohort of 1725 patients, 289 (16.7%) experienced a total of 439 metastatic infection events within the 90-day follow-up period. The majority of metastatic infections (approximately 85%) occurred within the first 7 days following diagnosis. The incidence of metastatic infections varied significantly with the primary focus of SAB, being highest in patients with endocarditis at 73.4%. The lung was the most frequent metastatic site (23.7%), followed by bones and joints (16.8%) and the central nervous system (12.3%). The distribution of metastatic sites significantly differed according to the primary infection focus. Conclusions: Our study findings provide essential insights into the risk and distribution of metastatic infections in patients with SAB, highlighting the critical role of the timing and primary infection focus. These findings enable healthcare professionals to adopt a more proactive and targeted approach to managing patients with SAB.

Indexed as

endocarditismetastatic infectionprimary infection focusStaphylococcus aureusStaphylococcus aureus bacteremia

Identifiers

PMID40568004
PMCPMC12188215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.