ArticleOpen forum infectious diseases2025
Switching From Dual to Monotherapy for Gonorrhea is Associated With a Halving of Gonococcal Resistance to Azithromycin-A Modelling Study of MSM in Belgium.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Heterogeneity of azithromycin resistance markers inNew microbes and new infections · 2026Review
- Mechanisms, management and prevention of anorectal sexually transmitted infections.Nature reviews. Gastroenterology & hepatology · 2026Review
- [Superbugs Neisseria gonorrhoeae und Mycoplasma genitalium : Therapeutic challenges driven by antimicrobial resistance].Dermatologie (Heidelberg, Germany) · 2026Review
- Enhancing female fertility by biomaterial-based regeneration of uterine tubes.Cell transplantationReview
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methods: We developed a network-based model for CT and NG transmission among MSM in Belgium to estimate the prevalence of CT, NG, and AR-NG in the population. The model simulates transmission of NG among 3 anatomical sites in a population of 10 000 MSM over 10 years. The effect of different treatment strategies was evaluated in terms of CT, NG, and AR-NG prevalence as well as antibiotic consumption. Results: Our model captured adequately well the observed azithromycin-resistance epidemic over a 10-year period in Belgium, with AR-NG increasing from 0% to 44%. Antibiotic consumption, and prevalences of NG and AR-NG decreased when ceftriaxone monotherapy was used against NG, while CT prevalence increased, compared to dual therapy. In the ceftriaxone monotherapy scenario, the prevalence of AR-NG was approximately half of that in the dual-therapy scenario (23%). Conclusions: Switching from dual to monotherapy was associated with a halving of the prevalence of AR-NG. These results provide further evidence to favor mono- over dual therapy for the treatment of gonorrhea.
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