Evidence map›Paper›PMID 40567893›Full record

ArticleNeuroimage. Reports2025

Brain perfusion and blood-brain barrier permeability in systemic lupus erythematosus patients: Associations with disease activity, cognitive dysfunction, fatigue and pain.

Tim Salomonsson, Kristoffer A Zervides, Andreas Jönsen, Malte Knutsson, Ronnie Wirestam, Jimmy Lätt, Anders A Bengtsson, Linda Knutsson, Pia C Sundgren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tim SalomonssonDepartment of Clinical Sciences, Diagnostic Radiology, Lund University, Skåne University Hospital, 221 85, Lund, Sweden.
Kristoffer A ZervidesDepartment of Clinical Sciences, Rheumatology, Lund University, Skåne University Hospital, 222 42, Lund, Sweden.
Andreas JönsenDepartment of Clinical Sciences, Rheumatology, Lund University, Skåne University Hospital, 222 42, Lund, Sweden.
Malte KnutssonDepartment of Clinical Sciences, Diagnostic Radiology, Lund University, Skåne University Hospital, 221 85, Lund, Sweden.
Ronnie WirestamDepartment of Medical Radiation Physics, Lund University, 221 85, Lund, Sweden.
Jimmy LättDepartment of Medical Imaging and Physiology, Skåne University Hospital, 221 85, Lund, Sweden.
Anders A BengtssonDepartment of Clinical Sciences, Rheumatology, Lund University, Skåne University Hospital, 222 42, Lund, Sweden.
Linda KnutssonDepartment of Medical Radiation Physics, Lund University, 221 85, Lund, Sweden.
Pia C SundgrenDepartment of Clinical Sciences, Diagnostic Radiology, Lund University, Skåne University Hospital, 221 85, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High disease activity, cognitive dysfunction (CD), fatigue and pain negatively affect the quality of life in patients with systemic lupus erythematosus (SLE). However, the impact on brain perfusion and blood-brain barrier (BBB) permeability remains incompletely understood. Therefore, we utilized 3 T dynamic susceptibility contrast magnetic resonance imaging to investigate these factors in a cohort of 66 female SLE patients. Normalized leakage corrected cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and the BBB leakage parameter K

Indexed as

Blood-brain barrier permeabilityBrain perfusionCognitive dysfunctionDynamic susceptibility contrast MRIFatiguePainSystemic lupus erythematosus

Identifiers

PMID40567893
PMCPMC12172694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.