Evidence map›Paper›PMID 40567888›Full record

ArticleNeuroimage. Reports2025

Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease.

Isobel Timothea French, Kuo-Hsuan Chang, Wei-Kuang Liang, Wen-Sheng Chang, Yen-Shi Lo, Yi-Ru Wang, Mei-Ling Cheng, Norden E Huang, Hsiu-Chuan Wu, Siew-Na Lim and 2 more

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Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Isobel Timothea FrenchInstitute of Cognitive Neuroscience, National Central University, No. 300 Jhongda Rd., Jhongli District, 32001, Taoyuan, Taiwan.
Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, No.5, Fusing St., Gueishan District, 333, Taoyuan, Taiwan.
Wei-Kuang LiangInstitute of Cognitive Neuroscience, National Central University, No. 300 Jhongda Rd., Jhongli District, 32001, Taoyuan, Taiwan.
Wen-Sheng ChangInstitute of Cognitive Neuroscience, National Central University, No. 300 Jhongda Rd., Jhongli District, 32001, Taoyuan, Taiwan.
Yen-Shi LoDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, No.5, Fusing St., Gueishan District, 333, Taoyuan, Taiwan.
Yi-Ru WangDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, No.5, Fusing St., Gueishan District, 333, Taoyuan, Taiwan.
Mei-Ling ChengDepartment of Biomedical Sciences, Chang Gung University, No 259, Wenhua 1st Rd, Guishan District, Taoyuan, Taiwan.
Norden E HuangInstitute of Cognitive Neuroscience, National Central University, No. 300 Jhongda Rd., Jhongli District, 32001, Taoyuan, Taiwan.
Hsiu-Chuan WuDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, No.5, Fusing St., Gueishan District, 333, Taoyuan, Taiwan.
Siew-Na LimDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, No.5, Fusing St., Gueishan District, 333, Taoyuan, Taiwan.
Chiung-Mei ChenDepartment of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, No.5, Fusing St., Gueishan District, 333, Taoyuan, Taiwan.
Chi-Hung JuanInstitute of Cognitive Neuroscience, National Central University, No. 300 Jhongda Rd., Jhongli District, 32001, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Flanker task measures visuospatial attention and assesses the attentional network by distinguishing pathways for enhancing information at attended regions and suppressing information at unattended ones (Kopp et al., 1996). In Parkinson's disease (PD), the attentional network is impaired due to dysfunctional fronto-subcortical circuits connected to the basal ganglia, disrupting response selection and inhibition. While electroencephalography (EEG) may reveal abnormalities of these circuits in PD, dynamic brain oscillations critical for interareal communications cannot be deciphered with conventional time-frequency analyses. Objective: To utilize the novel Holo-Hilbert Spectral Analysis (HHSA) to reveal dynamic EEG features of the Flanker task in PD patients and healthy normal controls for differentiating and elucidating attentional network deficits in patients. Methods: The novel HHSA was applied to uncover nonlinear features of the Flanker task EEG and to analyse connectivity using phase-amplitude cross-frequency coupling. Results: Holo-Hilbert transform (HHT) results showed an attenuated midfrontal theta (FMθ) in the congruency effect in PD patients, consistent with past studies. HHSA showed a loss of low-frequency amplitude modulations ( Conclusions: These visuospatial attention deficits of PD revealed with the advanced analytical method of the HHSA and HHCFPC may inaugurate further neurophysiological biomarkers for cognitive function evaluation in PD and related movement disorders.

Indexed as

Attentional networkCross-frequency phase clusteringElectroencephalographyParkinson's diseaseSpectral analysis

Identifiers

PMID40567888
PMCPMC12172737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.