Evidence map›Paper›PMID 40567861›Full record

ArticleNeuroimage. Reports2021

The development of cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder: A longitudinal fMRI study.

Bram Gooskens, Dienke J Bos, Jilly Naaijen, Sophie E A Akkermans, Anna Kaiser, Sarah Hohmann, Muriel M K Bruchhage, Tobias Banaschewski, Daniel Brandeis, Steven C R Williams and 5 more

Abstract read
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In one paragraph

Article in Neuroimage. Reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bram GooskensDepartment of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Dienke J BosDepartment of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Jilly NaaijenDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, the Netherlands.
Sophie E A AkkermansDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, the Netherlands.
Anna KaiserDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
Muriel M K BruchhageDepartment of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany.
Steven C R WilliamsDepartment of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
David J LythgoeDepartment of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Bob OranjeDepartment of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Sarah DurstonDepartment of Psychiatry, Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
TACTICS consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive behavior is a core symptom of Autism Spectrum Disorder (ASD) and Obsessive-Compulsive Disorder (OCD), and has been associated with impairments in cognitive control. However, it is unclear how cognitive control and associated neural circuitry relate to the development of repetitive behavior in children with these disorders. In a multicenter, longitudinal study (TACTICS; Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes), the development of cognitive control was assessed during late childhood using a longitudinal fMRI design with a modified stop-signal task in children with ASD or OCD, and typically developing (TD) children (baseline: N = 95 (8-12 y), follow-up: N = 53 (10-14 y), average interval: 1.48 y (sd: 0.36, range: 0.98-2.52 y). Stop-signal reaction time (SSRT) decreased over development, regardless of diagnosis. Repetitive behavior in children with ASD and OCD was not associated with performance on the stop-signal task. There were no whole-brain between-group differences in brain activity, but ROI-analyses showed increases in activity in right precentral gyrus over development for children with OCD. In sum, even though subtle differences were observed in the development of brain activity in children with OCD, overall the findings suggest that the development of cognitive control, as assessed by the stop signal task, is similar to typical in children with ASD and OCD.

Indexed as

Autism spectrum disorderCognitive controlfMRIObsessive-compulsive disorderRepetitive behavior

Identifiers

PMID40567861
PMCPMC12172903

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.