Evidence map›Paper›PMID 40567829›Full record

Trial reportDepression and anxiety2025

How Do Patients' Fear Prediction and Fear Experience Impact Exposure-Based Therapy for Panic Disorder With Agoraphobia? A Comprehensive Analysis of Fear Prediction.

Marina Hilleke, Thomas Lang, Sylvia Helbig-Lang, Georg W Alpers, Volker Arolt, Jürgen Deckert, Thomas Fydrich, Alfons O Hamm, Tilo Kircher, Jan Richter and 3 more

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Depression and anxiety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marina HillekeDepartment of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.ORCID 0000-0002-3557-2768
Thomas LangChristoph-Dornier-Foundation for Clinical Psychology, Bremen, Germany.ORCID 0000-0002-7016-4946
Sylvia Helbig-LangDepartment of Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
Georg W AlpersDepartment of Psychology, School of Social Sciences and Otto Selz Institute, University of Mannheim, Mannheim, Germany.ORCID 0000-0001-9896-5158
Volker AroltInstitute for Translational Psychiatry, Center for Psychosocial Medicine, University of Münster, Münster, Germany.ORCID 0000-0002-2445-9778
Jürgen DeckertDepartment of Psychiatry, Psychosomatics, and Psychotherapy, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-1008-4650
Thomas FydrichDepartment of Psychology, Humboldt-Universität of Berlin, Berlin, Germany.ORCID 0000-0003-0122-2302
Alfons O HammDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.ORCID 0000-0002-3352-6231
Tilo KircherDepartment of Psychiatry and Psychotherapy, Center for Mind, Brain and Behavior-CMBB, Philipps-University Marburg, Marburg, Germany.ORCID 0000-0002-2514-2625
Jan RichterDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.ORCID 0000-0002-7127-6990
Andreas StröhleDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.ORCID 0000-0003-0935-3702
Hans-Ulrich WittchenClinical Psychology and Psychotherapy RG, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, München, Germany.ORCID 0000-0002-6311-7711
Alexander L GerlachDepartment of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.ORCID 0000-0001-6794-5349

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expectancy violation has been proposed as a potential core mechanism of action in psychotherapy, particularly in exposure therapy for anxiety disorders. However, various relevant expectations have been discussed, and empirical studies examining their significance are still scarce. This study aimed to investigate one specific form of expectancy violation, based on Rachman's (1994) match-mismatch model, specifically by comparing expected and experienced fear and examining their relationship to safety behaviour during exposure in vivo in 268 patients meeting DSM-IV criteria for panic disorder with agoraphobia. Participants underwent exposure to a highly controlled manual-based cognitive behaviour therapy in a randomised multicenter psychotherapy study. Participants tended to overpredict fear during exposure. Both expected and experienced fear significantly decreased over the course of repeated exposure exercises, while prediction (in)accuracy (difference between expected and experienced fear) remained stable. The decrease in expected fear over time was a strong predictor of treatment outcomes for the Bodily Sensations Questionnaire (BSQ) and Panic and Agoraphobia Scale (PAS) at post. Even more, the reduction in expected fear was a significant predictor of treatment success across all outcome measures in the follow-up assessment. These findings suggest that violating excessive fear expectancies is not a necessary condition for symptom reduction during exposure therapy.

Indexed as

AgoraphobiaCognitive Behavioral TherapyFearImplosive TherapyPanic DisorderAdultFemaleHumansMaleMiddle AgedTreatment OutcomeYoung Adult

Identifiers

PMID40567829
PMCPMC12197478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.