Evidence map›Paper›PMID 40567820›Full record

ArticleNeuroimage. Reports2023

Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy.

Erik H Middlebrooks, Elena Greco, Xiangzhi Zhou, Vivek Gupta, Brin E Freund, Amit K Agarwal, Erin M Westerhold, Anteneh M Feyissa, William O Tatum, Sanjeet Grewal and 2 more

Abstract read
In one paragraph

Article in Neuroimage. Reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erik H MiddlebrooksDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Elena GrecoDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Xiangzhi ZhouDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Vivek GuptaDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Brin E FreundDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Amit K AgarwalDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Erin M WesterholdDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Anteneh M FeyissaDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
William O TatumDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Sanjeet GrewalDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Vishal PatelDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.
Shengzhen TaoDepartment of Radiology, Mayo Clinic, Jacksonville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.

Indexed as

7T MRIEDGEEpilepsyFocal cortical dysplasiaMP2RAGE

Identifiers

PMID40567820
PMCPMC12172902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.