ArticleNeuroimage. Reports2023
Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment.
Article in Neuroimage. Reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Age-Related Hearing Decline and Resting-State Networks.American journal of audiology · 2025Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mild cognitive impairment (MCI) and hearing loss (HL) have been separately associated with increased dementia risk. These highly co-occurring dementia risk factors are associated with aberrant functional brain connectivity. In individuals with HL aberrant functional connectivity has been associated with cognitive impairment. In individuals with MCI, aberrant brain connectivity has been associated with severity of cognitive impairment and conversion to dementia. Despite the high prevalence of HL in individuals with MCI, the relationship between the two is understudied, especially in the context of functional connectivity. Participants: include 94 older adults with MCI. Hearing measures include pure-tone hearing thresholds and speech-reception thresholds. In analyses with pure-tone hearing loss, participants were classified as having normal hearing (n = 60) or hearing loss (n = 34) based on a pure-tone screening protocol. We used independent component analyses on resting-state functional magnetic resonance imaging data to identify the default-mode network (DMN). Analysis of variance with covariate control was used to investigate DMN connectivity differences between the normally hearing individuals with MCI and individuals with MCI and pure-tone HL. A linear regression was used to investigate the relationship between speech-reception threshold and DMN connectivity in the whole sample.Compared to those with MCI and normal hearing, those with MCI and pure-tone HL had decreased connectivity between the DMN and the caudate and thalamus. There was no difference in DMN connectivity as a function of speech-reception threshold.Our findings indicate that in individuals with MCI, HL is associated with decreased connectivity between the DMN and regions important for sensory and cognitive processing. This suggests that the increased risk for cognitive decline and dementia in individuals with HL may be due to decreased DMN connectivity in individuals with HL.
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