Evidence map›Paper›PMID 40567815›Full record

ArticleJournal of Alzheimer's disease reports

Predicting brain health in community-dwelling elderly populations by integrating Gaussian mixture model and plasma biomarkers.

Yue Wang, Tianshu Zhu, Qian Cheng, Xiaolin Cui, Pengfei Zhang, Zhiming Lu, Alzheimer's Disease Neuroimaging Initiative (ADNI) *

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue WangDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Tianshu ZhuDepartment of Clinical Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Qian ChengDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xiaolin CuiDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Pengfei ZhangDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0002-2828-9067
Zhiming LuDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0003-1228-5739
Alzheimer's Disease Neuroimaging Initiative (ADNI) *

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Background: Alzheimer's disease (AD) is the most common type of dementia, and early screening is crucial for intervention. Objective: Currently, early screening for older adults without dementia primarily rely on cognitive scale. This study aims to explore a more feasible approach. Methods: Plasma biomarkers (Aβ Results: Plasma Aβ Conclusions: Our study indicated that the combination of GMM and plasma biomarkers for community screening shows promising potential in monitoring brain health among older adults without dementia. P-tau217 exhibited the best predictive value among the three plasma biomarkers.

Indexed as

Alzheimer's diseaseamyloidcognitive declineplasma biomarkersrisk stratificationtau

Identifiers

PMID40567815
PMCPMC12188080

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.