ReviewRSC medicinal chemistry2025
Current progress in targeting mitotic kinases in PDAC.
Review in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For a number of reasons, and unlike most other cancers, the mortality rate of PDAC is set to increase and, as such, it is predicted to become the second most common cause of cancer related mortality in the western world by the end of the current decade. One of the main reasons for this is the dire lack of robust therapeutic options. The clinical landscape of PDAC therapeutics is changing at an encouraging pace, exemplified by the breakthroughs in targeting not only KRAS but developing mutant-specific drugs against it. Nevertheless, the clinical community is still faced with a dire lack of effective therapeutics. The targeting of mitotic kinases - here limited to CDKs, Wee1, Chk1, Plk1 and the Aurora kinases - offers one potential avenue for exploitation. Here, we discuss ongoing efforts to target the mitotic kinases and present the advances that have been made for each, whilst also presenting the clinical and therapeutic perspectives for each category.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.