Evidence map›Paper›PMID 40567597›Full record

ArticleACS omega2025

In Vivo Comparison of Branched vs Linear Pegylation of a Capsule-Degrading Enzyme for Treatment of Anthrax.

Jennifer Chua, Devina Mathur, Hannah Lankford, J Matthew Meinig, Donald J Chabot, Patricia M Legler, Arthur M Friedlander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer ChuaUnited States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702, United States.
Devina MathurCenter for Bio/molecular Science and Engineering, U.S. Naval Research Laboratories, Washington, District of Columbia 20375, United States.
Hannah LankfordCenter for Bio/molecular Science and Engineering, U.S. Naval Research Laboratories, Washington, District of Columbia 20375, United States.
J Matthew MeinigUnited States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702, United States.
Donald J ChabotUnited States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702, United States.
Patricia M LeglerCenter for Bio/molecular Science and Engineering, U.S. Naval Research Laboratories, Washington, District of Columbia 20375, United States.ORCID https://orcid.org/0000-0003-1196-1061
Arthur M FriedlanderUniformed Services University of Health Sciences, Bethesda, Maryland 20814, United States.ORCID https://orcid.org/0000-0002-5349-3158

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymers of d-glutamic acid (PDGA) form capsules of virulent strains of Bacillus anthracis. PDGA is antiphagocytic and weakly immunogenic; it enables the bacteria to evade innate immune responses. Capsule depolymerase (CapD) catalyzes the covalent anchoring of PDGA to the cell wall. There has been interest in developing CapD as a therapeutic to treat antibiotic-resistant anthrax infections. We previously showed that a His-tagged and circularly permuted (CP) CapD modified with a branched 3-prong polyethylene glycol (PEG) molecule termed PEG-CapD

Identifiers

PMID40567597
PMCPMC12191348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.