ArticleNeuroimage. Reports2022
Longitudinal changes in grey matter and cognitive performance over four years of healthy aging.
Article in Neuroimage. Reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Article
- Molecular neuroimaging of Parkinson's disease: association of motor and non-motor symptoms with synaptic density, dopaminergic and serotonergic systems.Neuroimage. Reports · 2026Article
- Different structural brain patterns and their association with executive function and general cognitive ability in cognitively normal elderly adults.Frontiers in aging neuroscience · 2026Article
- Associations Between High-Density Lipoprotein Cholesterol Efflux and Brain Grey Matter Volume.Journal of clinical medicine · 2024Article
- Towards a neurodevelopmental cognitive perspective of temporal processing.Communications biology · 2024Review
- Associations between lifestyle, genetic risk for Alzheimer's disease, and longitudinal brain atrophy in the UK Biobank (Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Background: Normal aging is known to include declines in several cognitive domains, with parallel grey matter atrophy. However, there are inconsistencies in the largely cross-sectional literature as to which regions of grey matter show change over time, with some investigations reporting whole brain and others reporting more focal regions of atrophy. More longitudinal analyses are needed to better understand the neurostructural and functional changes that occur gradually in older adulthood. Objective: The aim of the current study was to investigate changes in cognitive performance and grey matter atrophy in a sample of healthy older adults over four years. Methods: MRI and cognitive data were retrieved from the Alzheimer's Disease Neuroimaging Initiative database for 35 participants in the cognitively normal cohort at two time points separated by four years (mean age at baseline = 75.02, Results: Results indicated widespread grey matter atrophy, including frontal, temporal, and subcortical regions. Cognitive performance was largely stable, with the exception of executive function, which showed significant decline over time. Conclusion: Findings indicate that cognitive abilities are largely preserved over a four year period, even when grey matter atrophy is present in the aging brain.
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Registered trials
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