Evidence map›Paper›PMID 40567533›Full record

ArticleSAGE open medical case reports2025

Merkel cell carcinoma in a psoriasis patient on long-term ixekizumab therapy: A case report.

Saba R Malik, Thomas G Salopek, John Walker, Robert Gniadecki

Abstract readCase Reports
In one paragraph

Article in SAGE open medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Saba R MalikDivision of Dermatology, University of Alberta, Edmonton, AB, Canada.
Thomas G SalopekDivision of Dermatology, University of Alberta, Edmonton, AB, Canada.
John WalkerDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Robert GniadeckiDivision of Dermatology, University of Alberta, Edmonton, AB, Canada.ORCID https://orcid.org/0000-0002-2310-8300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 69-year-old male receiving ixekizumab for plaque psoriasis presented with violaceous dermal nodules in a sporotrichoid pattern on the right distal lower leg. Biopsy and imaging led to the diagnosis of stage IIIB Merkel cell carcinoma. Treatment with avelumab, chemotherapy, and radiotherapy led to partial remission, but 4 years later, he succumbed to the disease. Ixekizumab-associated immunosuppression may have contributed to Merkel cell carcinoma development, a tumor known to occur more frequently in immunocompromised individuals.

Indexed as

ixekizumabMerkel cell carcinomapsoriasis

Identifiers

PMID40567533
PMCPMC12188051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.