Evidence map›Paper›PMID 40567506›Full record

ArticleSchizophrenia research. Cognition2025

Brain functional connectivity associated with cognitive deficits in younger patients at first episode of schizophrenia.

Na Liu, Lihua Xu, Xiaofeng Guan, Ansi Qi, Fei Liu, Chengqing Yang, Xiangyun Long, Junjuan Zhu, Nan Huang, Jie Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research. Cognition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Na LiuDepartment of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, PR China.
Lihua XuNeuromodulation Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
Xiaofeng GuanDepartment of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, PR China.
Ansi QiDepartment of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, PR China.
Fei LiuDepartment of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, PR China.
Chengqing YangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Xiangyun LongDepartment of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, PR China.
Junjuan ZhuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Nan HuangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Jie ZhangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Yi XuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Jing ChenShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Huan HuangDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Jijun WangNeuromodulation Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
Zheng LuDepartment of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive deficits are a core feature of schizophrenia and are influenced by the age at onset of psychosis. Both preclinical and early-onset schizophrenia patients exhibit abnormalities in the frontal cortex, parahippocampus, precuneus, and hippocampus-regions that are closely associated with cognitive deficits. This study examines whether cognitive-related functional connectivity (FC) within these regions differs in first-episode schizophrenia (FES) patients with varying ages of onset. Methods: FES patients (ages 18-45, Results: Significant cognitive differences were observed between the four groups (H = 13.447, Conclusion: Earlier onset schizophrenia is associated with more severe cognitive deficits and specific impairments in brain functional connectivity. These findings highlight the importance of considering age of onset when assessing cognitive and neural dysfunction in schizophrenia.

Indexed as

Age at onset of psychosisCognitive deficitsFirst episode of schizophreniaFunctional connectivityROI-to-ROI

Identifiers

PMID40567506
PMCPMC12190903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.