ArticleNeuroimage. Reports2025
Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample.
Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global aging population has led to a significant rise in dementia and cognitive decline, with Alzheimer's disease as the primary cause. Early detection of mild cognitive impairment (MCI), a prodromal stage of dementia, is critical for timely intervention. The Mini-Mental State Examination (MMSE) is commonly used for cognitive screening, yet its limitations-such as ceiling effects and educational biases-may hinder the early identification of subtle cognitive impairments. This cross-sectional study employed voxel-based morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) to explore brain regions positively correlated with MMSE scores in a cohort of 510 participants. Significant gray matter volume (GMV) reductions were observed in the bilateral lateral frontal lobes, left medial frontal lobe, left hippocampus, left anterior cingulate cortex (ACC), and bilateral inferior temporal gyri in association with lower MMSE scores. Participants were classified into three groups-Normal Cognition (NC), MCI, and Dementia (D)-based on MMSE cutoff values. Compared to the NC group, the MCI group exhibited significant GMV reductions in the left hippocampus, left parahippocampal gyrus, left ACC, and right ventromedial prefrontal cortex (vmPFC). The D group showed further GMV reductions in the bilateral hippocampus and left inferior temporal gyrus compared to the MCI group. These findings highlight the clinical utility of VBM-based structural MRI in assessing localized brain atrophy associated with cognitive decline, supporting its potential role in early diagnosis and intervention for MCI. Further research integrating longitudinal studies and multimodal biomarkers is warranted to enhance diagnostic accuracy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.