Evidence map›Paper›PMID 40567448›Full record

ArticleNeuroimage. Reports2025

Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults with

Jenna K Blujus, Michael W Cole, Elena K Festa, Stephen L Buka, Stephen P Salloway, William C Heindel, Hwamee Oh, Alzheimer's Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jenna K BlujusDepartment of Cognitive and Psychological Sciences, Brown University, Providence, 02912, USA.
Michael W ColeCenter for Molecular & Behavioral Neuroscience, Rutgers University, Newark, 07102, USA.
Elena K FestaDepartment of Cognitive and Psychological Sciences, Brown University, Providence, 02912, USA.
Stephen L BukaDepartment of Epidemiology and Population Health, Brown, University, Providence, 02912, USA.
Stephen P SallowayDepartment of Psychiatry and Human Behavior, Brown University, Providence, 02912, USA.
William C HeindelDepartment of Cognitive and Psychological Sciences, Brown University, Providence, 02912, USA.
Hwamee OhDepartment of Cognitive and Psychological Sciences, Brown University, Providence, 02912, USA.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Mechanisms of Risk and Resilience to Age-Related Cognitive Decline: A 60-Year Prospective Prenatal CohortR01AG069265 · NIA · BROWN UNIVERSITY · PI BUKA, STEPHEN L, HEINDEL, WILLIAM C · 2020 to 2024
$5.4M
Developing novel cognitive and neuroimaging markers of early Alzheimers disease pathologiesR01AG068990 · NIA · BROWN UNIVERSITY · PI OH, HWAMEE · 2020 to 2024
$4.0M
Advancing the Research Careers of Women and PEERs in Brain ScienceR25NS124530 · NINDS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Diane Lipscombe · 2022 to 2026
$1.3M
Brain Science Compute ClusterS10OD025181 · OD · BROWN UNIVERSITY · PI SANES, JEROME N · 2019 to 2019
$600k
NIA NIH HHS R01 AG068990NIA NIH HHS R01 AG069265NIA NIH HHS U01 AG024904NIH HHS S10 OD025181NINDS NIH HHS R25 NS124530
6 · The paper itself

Abstract

Several neural mechanisms underlying resilience to Alzheimer's disease (AD) have been proposed, including redundant neural connections between the posterior hippocampi and all other brain regions, and global functional connectivity of the left frontal cortex (LFC). Here, we investigated if functional redundancy of the hippocampus (HC) and LFC underscores neural resilience in the presence of early AD pathologies. From the ADNI database, cognitively normal older adults (CN) (N = 220; 36 % A

Indexed as

AgingAlzheimer's diseaseBeta-amyloid plaquesFunctional magnetic resonance imagingGraph theoryResilience

Identifiers

PMID40567448
PMCPMC12172829

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.