ArticleLaryngoscope investigative otolaryngology2025
Micro-CT Analysis of Rodent Temporal Bones: Identifying Optimal Species for Otological Research.
Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment.Research (Washington, D.C.) · 2026Review
- Micro-CT Analysis of Rodent Temporal Bones: Identifying Optimal Species for Otological Research.Laryngoscope investigative otolaryngology · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Objectives: Rodents are used in most otological research studies and the choice of the most appropriate animal model may be crucial in studies of ear diseases and in the development of effective treatments. Here, we used micro-CT to compare temporal bone anatomy between four rodent model animals (guinea pigs, gerbils, rats, and mice) and humans, aiming to better characterize the anatomy of the inner and middle ear, and facial nerve to support informed animal model selection in otologic research. Methods: We generated three-dimensional reconstructions and measured the various middle (tympanic membrane, ossicular chain, and facial nerve) and inner (cochlea, vestibular labyrinth) ear structures. Results: Each structure of the middle or inner ear of each rodent was described and measured. Conclusion: This micro-CT analysis of rodents can guide researchers in their choice of the most suitable middle or inner ear models based on the specific anatomic area of interest. Our findings highlight the strengths and limitations of each species, providing essential insight that could enhance the precision and applicability of otological studies. Level of Evidence: 4.
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