ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2025
Association between in-hospital antibiotic use and long-term outcomes in critically ill patients.
Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Risk Prediction of Multidrug-Resistant Infections in Pediatric Burn Patients with Hospital-Acquired Infections: A Retrospective Cohort Study.Plastic and reconstructive surgery · 2026Article
- Comment on "Predicting carbapenem-resistant Enterobacteriaceae infections in pediatric liver transplant recipients".World journal of pediatrics : WJP · 2026Article
- Antibiotic-induced gut microbiota dysbiosis in the PICU: mechanisms, clinical outcomes, and management strategies - a narrative review.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Objective: To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design: Prospective observational study. Setting: 611-bed, quaternary care academic medical center in the United States. Patients: 126 critically ill adults (mean age 68.1 ± 15.6 yr, 51.6% male, median APACHE II score 20.5 [IQR 15-25]); 71.4% met sepsis criteria. Methods: Secondary infection was defined as ≥3 consecutive antibiotic days within a year after the index sepsis admission. Multivariate analyses adjusted for age, APACHE II score, BMI, and glucocorticosteroid dose. Time-to-event analysis employed Cox proportional hazards modeling; cumulative infection burden was assessed via nonparametric tests using normalized antibiotic exposure (AD as a proportion of days alive). Results: Within 30 days, longer AD correlated with increased hospital stay; each additional antibiotic day added ∼0.93 hospital days ( Conclusions: Extended AD, in critically ill patients, prolongs hospitalization without reducing mortality or readmission rates. These findings highlight the importance of robust antibiotic stewardship practices, where shorter, targeted regimens may minimize unintended complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.