ArticleFrontiers in pharmacology2025
Polymethoxyflavones extracted from
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute lung injury (ALI), a critical respiratory condition, often escalates into acute respiratory distress syndrome, which is associated with significant morbidity and mortality. Methods: A comprehensive literature review and database search within Chemistry Database were conducted to compile a complete profile of the metabolites identified in Results: 17 known MBC were identified in which 7 active metabolites of flavonoids were used as predictive targets. 122 target genes associated with both MBC and ALI were tested for KEGG and GO enrichment analyses, which indicated these target genes involvement in antioxidant, anti-inflammatory, and anti-apoptotic pathways. The PMFs were extracted from Conclusion: PMFs inhibited the expression of inflammatory cytokines and reduced oxidative stress injury to resist apoptosis in lung. Moreover, PMFs attenuated LPS-induced ER stress activation by regulating ER stress related targets, which in turn alleviated ALI.
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