ArticleNeuroimage. Reports2022
Hemodynamic correlates of fluctuations in neuronal excitability: A simultaneous Paired Associative Stimulation (PAS) and functional near infra-red spectroscopy (fNIRS) study.
Article in Neuroimage. Reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
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- NIRSTORM: a Brainstorm extension dedicated to functional near-infrared spectroscopy data analysis, advanced 3D reconstructions, and optimal probe design.Neurophotonics · 2025Article
- Hierarchical Bayesian modeling of the relationship between task-related hemodynamic responses and cortical excitability.Human brain mapping · 2023Article
- Phantom limb therapy improves cortical efficiency of the sensorimotor network in a targeted muscle reinnervation amputee: a case report.Frontiers in neuroscience · 2023Article
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9 authors.
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Abstract
Background: The relationship between task-related hemodynamic activity and brain excitability is poorly understood in humans as it is technically challenging to combine simultaneously non-invasive brain stimulation and neuroimaging modalities. Cortical excitability corresponds to the readiness to become active and as such it may be linked to metabolic demand. Hypotheses: Cortical excitability and hemodynamic activity are positively linked so that increases in hemodynamic activity correspond to increases in excitability and vice-versa. Methods: Magnitudes of excitability and hemodynamic activity were investigated via simultaneous Transcranial Magnetic Stimulation (TMS) and functional Near Infrared Spectroscopy (fNIRS). Sixteen healthy subjects participated in a sham-controlled, pseudorandomized, counterbalanced study with PAS (PAS10/PAS25/Sham) on the right primary motor cortex (M1). The relationship between M1 excitability (Motor Evoked Potentials, MEP) and hemodynamic responses to finger tapping reconstructed via personalized fNIRS was assessed. Results: Hemodynamic activity exhibited a significant correlation with cortical excitability: increased HbO and HbR (absolute amplitude) corresponded to increased excitability and vice-versa (r = 0.25; p = 0.03 and r = 0.16; p = 0.17, respectively). The effect of PAS on excitability and hemodynamic activity showed a trend of positive correlation with MEP ratios (post-PAS/pre-PAS) linked to HbO and HbR ratios (r = 0.19, p = 0.29; r = 0.18, p = 0.30, respectively). Conclusions: TMS-fNIRS is a suitable technique for simultaneous investigation of excitability and hemodynamic responses and indicates a relationship between these two cortical properties. PAS effect is not limited to cortical excitability but also impacts hemodynamic processes. These findings have an impact on the application of neuromodulatory interventions in patients with neuropsychiatric disorders.
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