ArticleNeuroimage. Reports2021
Basal ganglia activation localized in MEG using a reward task.
Article in Neuroimage. Reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills.Nature human behaviour · 2024Trial
- The Dynamic Interaction between Procedural Learning and Resting-State Functional Connectivity in Self-Limited Focal Epilepsies.Brain topography · 2025Article
- Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases.Nature communications · 2024Article
- Neuroimaging to Facilitate Clinical Trials in Huntington's Disease: Current Opinion from the EHDN Imaging Working Group.Journal of Huntington's disease · 2024Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basal ganglia are a crucial component of neural networks underlying reward response and many other behaviors. Magnetoencephalography (MEG) can be used to non-invasively study the spatiotemporal dynamics of activity in neural networks. However, challenges associated with detecting deep sources has caused many to doubt the ability of MEG to detect basal ganglia signals. In this study, we employed a gambling task to assess the feasibility of using MEG to investigate basal ganglia-cortical networks during reward processing. Participants gambled to win or lose 5 or 25 cents and received unexpected high-value rewards of 50 cents at random intervals. We contrasted activity between reward conditions in the beta (15-30 Hz), gamma (30-60 Hz), and high gamma (60-150 Hz) bands. We found differences in oscillatory power in the beta and high gamma bands while contrasting the large reward condition with both the small reward and large loss conditions. Basal ganglia activity was localized to the caudate, putamen, and globus pallidum, while cortical activity appeared primarily in parietal and temporal areas. Our results show robust basal ganglia power differences in response to reward and corroborate animal literature showing beta and high gamma activation in the striatum. This experiment demonstrates that it is possible to study basal ganglia activity using MEG and reveals specific characteristics of the normal reward response that will inform future research.
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