ArticleEnvironment & health (Washington, D.C.)2025
Unveiling the Hidden Threat: Per- and Polyfluoroalkyl Substance Pollution's Distinct Traits and Crucial Impacts on Lung Function in Chinese Plateau Populations.
Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Associations of Serum Per- and Polyfluoroalkyl Substance Concentrations with Dyslipidemia and Its Subtypes in an Adult Population from Shandong, East China.Environment & health (Washington, D.C.) · 2026Article
- Urine-to-Blood Partitioning of Per- and Polyfluoroalkyl Substances in Human Biomonitoring: Implications for Environmental Exposure Analysis and Bioaccumulation Assessment.Molecules (Basel, Switzerland) · 2026Review
- From environment to organs: individual and combined effects of MPs and PFAS on urinary system health.Frontiers in physiology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plateau region is conventionally regarded as a "clean land" with minimal environmental pollution, leading to scarce research on the distribution of emerging pollutants such as per- and polyfluoroalkyl substances (PFAS) and their effects on the health of plateau inhabitants. To understand that, we studied participants from two representative towns in Gannan Tibetan Autonomous Prefecture, Gansu Province, China. Lung function parameters (FVC%, FEV1%, and FEV1/FVC) were measured, while PFAS concentrations in urine and indoor dust were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). We measured the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-epi-prostaglandin F2α (8-epi-PGF2α), and malondialdehyde (MDA) in urine. The results demonstrated a preponderance of short-chain PFAS in urine, with PFBS, PFPeA, and PFBA showing the highest detection rates. PFBA had the highest median concentration at 0.47 ng/mL. Similarly, in indoor dust, PFBA was the most frequently detected, followed by PFOA, with median concentrations of 0.56 and 0.44 ng/g, respectively. Multiple PFAS compounds showed significant inverse correlations with FVC% and FEV1%. PFAS exposure was associated with elevated oxidative stress biomarker levels (8-OHdG, 8-epi-PGF2α, and MDA), and their synergistic interaction aggravated the decline in lung function. This research provides valuable evidence of PFAS exposure patterns in the plateau population, highlighting the dominance of short-chain PFAS compounds and the concerning link between PFAS exposure and impaired lung function.
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Registered trials
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