Evidence map›Paper›PMID 40567267›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Breath and Blood Metabolomics: A Comparative Study Using SESI-HRMS/MS and UHPLC-ESI-HRMS/MS.

Zhifeng Tang, Jianming Yang, Xin Xu, Keda Zhang, Huiling Wang, Xin Luo, Mingliang Fang, Tao Huan, Xue Li

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In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhifeng TangCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.
Jianming YangGuangdong Provincial Key Laboratory of Speed Capability Research, Su Bingtian Center for Speed Research and Training, School of Physical Education, Jinan University, Guangzhou 510632, China.
Xin XuDepartment of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.
Keda ZhangCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.ORCID https://orcid.org/0000-0001-7512-3281
Huiling WangCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.
Xin LuoCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.
Mingliang FangDepartment of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-2204-9783
Tao HuanDepartment of Chemistry, Faculty of Science, University of British Columbia, Vancouver Campus, 2036 Main Mall, Vancouver V6T 1Z1, BC, Canada.ORCID https://orcid.org/0000-0001-6295-2435
Xue LiCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.ORCID https://orcid.org/0000-0001-9247-0584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breath metabolomics enables noninvasive and rapid acquisition of metabolic information by detecting volatile organic compounds (VOCs) in exhaled breath. Secondary electrospray ionization high-resolution tandem mass spectrometry (SESI-HRMS/MS) offers the highest coverage for detecting breath metabolites among current real-time breath analysis techniques. Although it has been generally recognized that metabolites in breath originate from the blood, a molecular-level understanding of the characteristics of metabolites in both breath and blood remains insufficient. In this study, nontargeted analyses of breath and blood samples from 11 healthy volunteers were performed using SESI-HRMS/MS and ultrahigh performance liquid chromatography electrospray ionization high-resolution tandem mass spectrometry (UHPLC-ESI-HRMS/MS), respectively. Tandem mass spectrometry was employed for metabolite annotation. Twenty-six breath-unique metabolites and 73 blood-unique metabolites were identified. Besides, seven metabolites were found in both breath and blood, including 7-oxabicyclo [2.2.1] heptane, levulinic acid, indole, pyroglutamic acid, malic acid, glutamic acid, and histidine. Intriguingly, the correlation of these metabolites between breath and blood was low (

Indexed as

blood metabolomicsbreath metabolomicsmetabolite identificationmetabolomics comparisonSESI-HRMS/MSUHPLC-ESI-HRMS/MS

Identifiers

PMID40567267
PMCPMC12186209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.