SynthesisNeuropsychopharmacology reports2025
Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta-Analysis.
Synthesis in Neuropsychopharmacology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta-Analysis.Neuropsychopharmacology reports · 2025Pooled it
- Combination Lorcaserin and Betahistine Treatment Improves Cognitive Dysfunction and Dopaminergic Neuron Activity in a Rat Model of Diet-Induced Obesity.Brain sciences · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimWhether histamine H3 receptor antagonists (H3R-ANTs)/inverse agonists (H3R-IAs) provides benefit for the treatment of schizophrenia remains unclear. This meta-analysis was conducted to address the above clinical question.
methodsCognitive Function Scale's composite score (primary), seven domains of cognitive function (speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning/problem solving, and social cognition) score, University of California San Diego Performance-Based Skills Assessment score, psychopathology scales score, discontinuation rate, and incidence of individual adverse events were among the study outcomes. The standardized mean differences (SMD) or risk ratios (RR) with 95% confidence intervals (CIs) were calculated.
resultsOur meta-analysis included 11 double-blind, randomized, placebo-controlled trials (n = 754). Our study evaluated ABT-288, betahistine, betahistine+reboxetine, GSK239512, MK-0249, and pitolisant. Betahistine has an H1-receptor agonistic reaction and H3-receptor antagonistic reaction, while other drugs only have an H3-receptor antagonistic/inverse agonistic reaction. Hence, we conducted a meta-analysis for all outcomes divided by betahistine or other pooled H3R-ANTs/H3R-IAs. The study results show that betahistine outperformed placebo in the improvement of overall cognitive symptoms (SMD [95% CI] = -0.61 [-1.03, -0.18]), speed of processing (-0.44 [-0.87, -0.02]), attention/vigilance (-0.43 [-0.85, -0.01]), working memory (-0.48 [-0.90, -0.06]), verbal learning (-0.62 [-1.04, -0.19]), visual learning (-0.57 [-1.00, -0.15]), and betahistine+reboxetine was superior in the improvement of depressive symptoms (-4.04 [-5.10, -2.97]). Pitolisant outperformed placebo in depressive symptom improvement (-3.24 [-4.22, -2.26]). However, the results were derived from one betahistine, betahistine+reboxetine, or pitolisant study. Other pooled H3R-ANTs/H3R-IAs revealed risk of insomnia (RR [95% CI] = 2.18 [1.05, 4.55]). However, no differences were observed in other any outcomes between betahistine or other pooled H3R-ANTs/H3R-IAs and placebo.
conclusionsSome H3R-ANTs/H3R-IAs might provide benefit for the treatment of cognitive symptoms and depressive symptoms in individuals afflicted with schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.