Evidence map›Paper›PMID 40567120›Full record

ArticleJournal of child neurology2026

Sleep Problems and Clinical Severity in Rett Syndrome.

Sarika U Peters, Cary Fu, Althea Robinson Shelton, Jeffrey L Neul, Beth Malow

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarika U PetersDepartment of Pediatrics, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-7439-5402
Cary FuDepartment of Pediatrics, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Althea Robinson SheltonDepartment of Neurology, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey L NeulDepartment of Pediatrics, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-5628-5872
Beth MalowDepartment of Neurology, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Clinical validation of at-home methods of sleep assessment in Rett SyndromeR21TR003942 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PETERS, SARIKA U · 2021 to 2022
$458k
NCATS NIH HHS R21 TR003942NICHD NIH HHS P50 HD103537
6 · The paper itself

Abstract

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is often associated with sleep problems. To date, few studies have examined how sleep problems correspond to aspects of clinical severity in Rett syndrome. In this study, we examined how sleep architecture and sleep-disordered breathing correspond to psychometrically validated outcome measures that are being used in clinical trials. Thirteen participants (mean [M] = 5.96 years, standard deviation [SD] = 2.6), all with confirmed pathogenic variants in

Indexed as

Rett SyndromeSleep Wake DisordersAdolescentChildChild, PreschoolFemaleHumansMaleMethyl-CpG-Binding Protein 2PolysomnographySeverity of Illness IndexSleep Apnea, ObstructiveMethyl-CpG-Binding Protein 2clinical severityRettsleep

Identifiers

PMID40567120
PMCPMC12354067

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.