Evidence map›Paper›PMID 40567008›Full record

ArticleJournal of Parkinson's disease2025

Depressive symptoms can negatively influence patient reported disease severity after subthalamic nucleus stimulation for Parkinson's disease.

Christine Girges, Alexis de Roquemaurel, Nirosen Vijiaratnam, Jennifer Foley, Joseph Candelario, Maricel Salazar, Catherine Milabo, John Esperida, Tim Grover, Harith Akram and 5 more

Abstract read
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In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christine GirgesDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-5019-6812
Alexis de RoquemaurelInstitute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK.
Nirosen VijiaratnamClinical Research Centre for Movement Disorders and Gait, Kingston Centre, Parkinson's Foundation Centre of Excellence, Monash Health, Cheltenham, Victoria, Australia.
Jennifer FoleyDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-5083-2823
Joseph CandelarioDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Maricel SalazarDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Catherine MilaboDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
John EsperidaDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Tim GroverDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Harith AkramDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0002-2899-628X
Jonathan HyamDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Marie T KrügerDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Ludvic ZrinzoDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0002-6013-4946
Patricia LimousinDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0001-5668-5545
Thomas FoltynieDepartment of Clinical and Movement Neurosciences, University College London, London, UK.ORCID 0000-0003-0752-1813

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundDepression can negatively influence an individual's perception of their disease. Although subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson's disease (PD), some patients do not appreciate benefits despite showing objective improvements in motor function.ObjectiveWe explored the impact of depressive symptoms on self-reported outcomes of PD severity in patients who underwent STN-DBS.MethodsAssessments took place preoperatively and 2-years after surgery. Patients completed the Hospital Anxiety and Depression Scale (HADS), Unified Parkinson's Disease Rating Scale (UPDRS) Parts 2 and 4, Gait and Falls Questionnaire, Parkinson's Disease Questionnaire-39 (PDQ-39), and the Non-motor Symptoms Scale. The UPDRS Part 3 (motor examination) was also performed. Patients were dichotomized into two groups (normal or high) based on their postoperative follow-up HADS depression score.ResultsEighteen patients (33.3%) were assigned to the high group (hHADS-D), and 36 patients (66.7%) were assigned to the normal group (nHADS-D). The UPDRS Part 3 OFF-medication score improved to a similar extent in both groups, and participants experienced a similar reduction in their levodopa equivalent daily dose following STN-DBS. Unlike the nHADS-D group, however, hHADS-D patients did not self-report improvements on any clinical outcome measure at follow-up from baseline, and instead indicated a significant worsening on the UPDRS Part 2 ON-medication and PDQ-39 cognition domain. This was not explicable by their preoperative non-motor symptom burden, nor changes in dopaminergic medications. There were no differences between groups in terms of proportion using anti-depressants, surgical complications or postoperative side effects.ConclusionsDepressive symptoms may play a significant role in subjective self-reporting, and should be carefully considered when evaluating STN-DBS effectiveness and managing patients postoperatively.

Indexed as

Deep Brain StimulationDepressionParkinson DiseasePatient Reported Outcome MeasuresSubthalamic NucleusAgedFemaleHumansMaleMiddle AgedSeverity of Illness Indexdeep brain stimulationdepressive symptomsoutcome measuresParkinson's disease

Identifiers

PMID40567008
PMCPMC13347502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.