ArticleChemistry & biodiversity2025
Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is an increasing threat to public health, with alarming estimates of mortality rates. In this context, the clinical properties of Varronia curassavica Jacq. are highlighted due to its biological and pharmacological activities. This study aims to analyze the phytochemical composition of the essential oil from V. curassavica (EOVC) and its antibiofilm activity against Gram-positive and Gram-negative strains. The essential oil was extracted from the leaves using hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS), phytochemical analysis of EOVC identified 97.36% of the total composition, predominantly composed of monoterpenes (α-pinene at 44.46%) and sesquiterpenes (β-caryophyllene at 21.82%). Antibiofilm tests were performed on five bacterial strains (both Gram-positive and Gram-negative) to evaluate the ability to inhibit and eradicate biofilms, with statistical analysis of the results. Antibiofilm formation tests demonstrated that EOVC exhibited efficacy against Staphylococcus aureus and Staphylococcus epidermidis, with minimum inhibitory concentrations (MIC) of 1.024 and 10.240 µg/mL, respectively, values comparable to those observed for the reference antibiotic. In addition, at high concentrations (10 × MIC), EOVC inhibited biofilm development by Streptococcus mutans and Enterococcus faecalis, achieving performance similar to that of gentamicin. In biofilm eradication assays, EOVC showed effective activity against E. faecalis, S. epidermidis, and S. aureus at concentrations of 10.240 µg/mL, equivalent to gentamicin. However, resistance was found in strains of Pseudomonas aeruginosa and S. mutans, with P. aeruginosa showing the highest level of resistance to EOVC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.