Evidence map›Paper›PMID 40566759›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Clinical features, biomarker profiles, and neuroimaging characteristics in patients from memory clinic in china: The Shanghai Memory Study.

Jie Wang, Xiaoxi Ma, Jiaying Lu, Jie Wu, Zhenxu Xiao, Huiwei Zhang, Weiqi Bao, Saineng Ding, Li Zheng, Xiaoniu Liang and 5 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Utility ofAlzheimer's research & therapy · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jie WangDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoxi MaDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jiaying LuDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jie WuDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Zhenxu XiaoDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Huiwei ZhangDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Weiqi BaoDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Saineng DingNational Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Li ZhengDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoniu LiangDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yihui GuanDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Chuantao ZuoDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Ding DingDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Qianhua ZhaoDepartment and Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Shanghai Memory Study (SMS)

Funding

National Ministry of Science and Technology SQ2021AAA010157National Natural Science Foundation of China 82071200National Natural Science Foundation of China 82173599National Natural Science Foundation of China 82371429Shanghai Municipal Science and Technology Major Project 2018SHZDZX01Shanghai Municipal Science and Technology Major Project ZJ LAB
6 · The paper itself

Abstract

introductionDespite advances in biomarker assessment, molecular neuroimaging, and disease-modifying therapies for cognitive disorders, China lacks well-characterized clinical cohorts integrating comprehensive clinical assessments and multimodal biomarkers.

methodsThe Shanghai Memory Study (SMS), an ongoing hospital-based cohort, enrolled participants undergoing clinical/neuropsychological assessments, genotyping, multimodal imaging, and biospecimen collection.

resultsFrom 2012 to 2024, 2001 participants were enrolled: 115 cognitively unimpaired (CU), 938 with mild cognitive impairment (MCI), and 948 with dementia. Positron emission tomography (PET) scan revealed A+/T+ positivity rates of 15.8% in CU, 51.2% in MCI, and 100% in Alzheimer's disease dementia (ADD). Plasma tau phosphorylated at threonine 181 (p-tau181) level increased gradually across the AD continuum. Blood p-tau181 and 18F-Florzolotau PET showed comparable utility for amyloid status identification. In a subcohort of 251 amnestic MCI (aMCI) patients, low Aβ42/Aβ40 and elevated p-tau181 predicted 4.7-year ADD risk. DISCUSSION: By offering an integrated framework, SMS will facilitate the exploration of AD pathogenesis and the understanding of cognitive disorders. HIGHLIGHTS: The SMS is an ongoing prospective cohort study based on a memory clinic in China. The SMS has established a relatively large-scale dataset that includes clinical data, biofluid markers, MRI and PET imaging, and novel biomarkers. By offering an integrated framework, SMS aims to facilitate the exploration of AD pathogenesis and deepen our understanding of cognitive disorders.

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeuroimagingAgedAmyloid beta-PeptidesBiomarkersBrainChinaCohort StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsAlzheimer's diseasebiomarkerdementiaepidemiologyhospital‐based studyneuroimaging

Identifiers

PMID40566759
PMCPMC12198466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.