ArticleDiabetes, obesity & metabolism2025
Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.Diabetes, obesity & metabolism · 2025Article
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4 authors.
Funding
Abstract
aimsObesity is associated with functional alterations in the brain. Although spatial organisation changes in the brains of individuals with obesity have been widely studied, the temporal dynamics in their brains remain poorly understood. Therefore, in this study, we investigated variations in the intrinsic neural timescale (INT) across different degrees of obesity using resting-state functional and diffusion magnetic resonance imaging data from the enhanced Nathan Kline Institute Rockland Sample database. MATERIALS AND
methodsWe examined the relationship between the INT and obesity phenotypes using supervised machine learning, controlling for age and sex. To further explore the structure-function characteristics of these regions, we assessed the modular network properties by analysing the participation coefficients and within-module degree derived from the structure-function coupling matrices. Finally, the INT values of the identified regions were used to predict eating behaviour traits.
resultsA significant negative correlation was observed, particularly in the default mode, limbic and reward networks. We found a negative association with the participation coefficients, suggesting that shorter INT values in higher-order association areas are related to reduced network integration. Moreover, the INT values of these identified regions moderately predicted eating behaviours, underscoring the potential of the INT as a candidate marker for obesity and eating behaviours.
conclusionsThese findings provide insight into the temporal organisation of neural activity in obesity, highlighting the role of specific brain networks in shaping behavioural outcomes.
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