Evidence map›Paper›PMID 40566741›Full record

ArticleJournal of the American Geriatrics Society2025

Heterogeneity of Effect of Specialist Palliative Care for Black and Non-Hispanic White Older Adults With Metastatic Cancer.

Ling Guo, Komal P Murali, R Sean Morrison, May Hua

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Palliative medicine reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ling GuoDepartment of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Komal P MuraliNYU Rory Meyers College of Nursing, New York, New York, USA.ORCID https://orcid.org/0000-0003-2659-8795
R Sean MorrisonIcahn School of Medicine at Mount Sinai and James J Peters VA, Bronx, New York, USA.
May HuaDepartment of Anesthesiology, College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

Funding

Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI William W.,MPH, MD Hung · 2010 to 2026
$21.9M
Advanced-Stage Development of a Geriatric Palliative Care Research InfrastructureR33AG065726 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALDRIDGE, MELISSA DIANE, MORRISON, R. SEAN · 2020 to 2024
$3.4M
Determinants of Palliative Care Effectiveness for Patients with Metastatic CancerR37CA246565 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI May Hua · 2021 to 2026
$3.3M
Engage-D: DEsigNing Culturally Sensitive Care ManaGement for Hospice TrAnsitions for Diverse Persons LivinG with AdvancEd DementiaK23AG083125 · NIA · NEW YORK UNIVERSITY · PI Komal Patel Murali · 2024 to 2026
$586k
NCI NIH HHS R37 CA246565NCI NIH HHS R37CA246565NIA NIH HHS K23 AG083125NIA NIH HHS K23AG083125NIA NIH HHS P30 AG028741NIA NIH HHS P30AG028741NIA NIH HHS R33 AG065726NIA NIH HHS R33AG065726
6 · The paper itself

Abstract

backgroundAlthough racial disparities in end-of-life care exist, whether the effect of specialist palliative care (PC) on end-of-life outcomes differs by race is unknown.

methodsWe created a propensity-matched cohort of Black and non-Hispanic White (NHW) older adults with metastatic cancer who did and did not receive specialist PC in the last 6 months of life. End-of-life outcomes included hospice use, hospice enrollment ≥ 3 days, intensive care unit (ICU) use in the last 30 days of life, and use of chemotherapy in the last 14 days of life. We used Cox regression models to evaluate for the presence of interaction between specialist PC and race for all outcomes on the multiplicative scale using interaction terms, and on the additive scale using the relative risk due to interaction (RERI), attributable proportion (AP) and synergy index (SI).

resultsAfter 1:1 matching, 13,931 exposed and 13,931 unexposed older adults were included, of which 13.4% were Black. In comparison to those who did not receive specialist PC, both Black and NHW older adults who received specialist PC were more likely to use hospice (71.0% versus 52.4% for Black, p < 0.0001; 80.4% versus 63.2% for NHW, p < 0.0001), have hospice enrollment ≥ 3 days (65.5% versus 44.0% for Black, p < 0.0001; 74.2% versus 52.6% for NHW, p < 0.0001), and have less use of the ICU (16.4% versus 19.9% for Black, p = 0.0058; 11.3% versus 14.0% for NHW, p < 0.0001) or chemotherapy at the end-of-life (1.2% versus 2.4% for Black, p = 0.0075, 1.4% versus 3.4% for NHW, p < 0.0001). There was no evidence of multiplicative interaction or additive interaction for any outcome.

conclusionIn older adults with metastatic cancer, there was no evidence for heterogeneity of effect for specialist PC between Black and NHW patients, suggesting that differences in the efficacy of specialist PC are not responsible for racial disparities in end-of-life care.

Indexed as

Black or African AmericanHealthcare DisparitiesNeoplasmsPalliative CareTerminal CareWhiteAgedAged, 80 and overFemaleHospice CareHumansIntensive Care UnitsMaleNeoplasm MetastasisPropensity Scorehospiceintensive care unitsneoplasmspalliative care

Identifiers

PMID40566741
PMCPMC12354289

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.