Evidence map›Paper›PMID 40566619›Full record

ArticleLife (Basel, Switzerland)2025

Novel Acylated Naringin Enhances Propionate Release and Stimulates the Growth of Flavanone-Metabolizing Bacteria in an In Vitro Batch Fermentation Model.

Blanca Elizabeth Ruiz-Álvarez, José Daniel Padilla-de la Rosa, Marisela González Avila, Georgina Sandoval, Yves Desjardins

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Blanca Elizabeth Ruiz-ÁlvarezInstitute sur la Nutrition et les Aliments Fonctionnels (INAF) de l'Université Laval, Faculté des Sciences de l'Agriculture et de l'Alimentation, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-6397-350X
José Daniel Padilla-de la RosaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A. C. (CIATEJ), Guadalajara 44270, Jalisco, Mexico.ORCID 0000-0002-2554-3488
Marisela González AvilaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A. C. (CIATEJ), Guadalajara 44270, Jalisco, Mexico.ORCID 0000-0001-7799-2587
Georgina SandovalCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A. C. (CIATEJ), Guadalajara 44270, Jalisco, Mexico.ORCID 0000-0002-9105-0702
Yves DesjardinsInstitute sur la Nutrition et les Aliments Fonctionnels (INAF) de l'Université Laval, Faculté des Sciences de l'Agriculture et de l'Alimentation, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-0398-2797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of non-communicable diseases (NCDs) is strongly associated with gut microbiota (GM) imbalances and reduced short-chain fatty acid (SCFA) production, primarily driven by poor diet and microbial dysbiosis. Since SCFAs are crucial for gut health, immune regulation, and inflammation control, restoring their levels is a key therapeutic target. SCFA-acylated naringin derivatives offer a novel approach by enhancing SCFA delivery and modulating GM composition. In this study, we investigated the effects of naringin acetate and naringin propionate on SCFA production using a 24 h short-term in vitro batch fecal fermentation model with microbiota from two donors. Naringin propionate and naringin plus free propionate significantly increased propionate levels by 0.74 mM and 0.75 mM, respectively (

Indexed as

acylated SCFA moleculesgut microbiotanaringinSCFAs

Identifiers

PMID40566619
PMCPMC12193867

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.